jUploadr is a must if you have a boatload of photos to get up into Flickr. Drag n Drop, batch apply tags, names, descriptions, assign to sets and upload in the background.
After about 5 days or so, I managed to get about 3000 photos online. Not bad. Not bad at all. Now I just need to finis updating to MovableType 4.0 and get my Flickr feeds into my blog.